Nemadectin is a macrocyclic lactone antibiotic that demonstrates endectocidal and nematocidal activity. Differing only by the unsaturated side-chain extending from the 6,6-spiroketal core, this antibiotic is structurally similar to milbemycins and avermectins. Nemadectin has been used as starting material for the production of the veterinary anthelmintic, moxidectin, and its derivatives have been explored for their potential antiparasitic use.
