NO-LOSARTAN A

Angiotensin II is a hormone that plays an important role in regulating blood pressure.¹ Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT₁) receptor.² Losartan is a mammalian AT₁ receptor antagonist with a K_i value of 5-20 nM.³ In humans, losartan effectively controls hypertension while protecting renal function.⁴ Nitric oxide (NO) causes vasodilation and also inhibits platelet and neutrophil aggregation in the endothelium.^5,6 NO-losartan A possesses similar anti-hypertensive effects to losartan, with the addition of the vasodilating effects of NO release.⁷