Neurotensin, a hypotensive peptide first isolated from the bovine hypothalamus, neurotensin acts as a neurotransmitter and neurotransmodulator in the central nervous system, and also as a
local hormone in the small intestine. Neurotensin (NT) is a tridecapeptide that was originally isolated from extracts of the bovine hypothalamus
in 1973, based on its ability to cause a visible vasodilation
in the exposed cutaneous regions of anesthetized rats.