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ChemicalBook CAS DataBase List Mizolastine

Mizolastine

$21 - $1841

Product nameMizolastine
Cas No108612-45-9
MFC24H25FN6O
MW432.49
EINECS1308068-626-2
MDL NumberMFCD23140913

Synonyms

4(1h)-pyrimidinone,2-((1-(1-((4-fluorophenyl)methyl)-1h-benzimidazol-2-yl)-4-p ;iperidinyl)methylamino)- ;2-[[1-[1-[(4-fluorophenyl)methyl]benzoimidazol-2-yl]-4-piperidyl]-methyl-amino]-3h-pyrimidin-4-one;MIZOLASTINE;2-[[1-[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]-4-piperidinyl]methylamino]-4(1H)-pyrimidinone;Mizolastine HCl;2-[[1-[1-(4-fluorobenzyl)benzimidazol-2-yl]-4-piperidyl]-methyl-amino]-1H-pyrimidin-6-one;2-[[1-[1-[(4-fluorophenyl)methyl]benzimidazol-2-yl]piperidin-4-yl]-methyl-amino]-1H-pyrimidin-6-one

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Price

49 prices

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Apolloscientific AK Scientific aablocks AvaChem ChemScene ApexBio Technology Cayman Chemical Crysdot TCI Chemical TRC Sigma-Aldrich American Custom Chemicals Corporation Chem-Impex AHH Matrix Scientific DC Chemicals Usbiological
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25mg 50mg 10mm(in1mldmso) 5mg 10mg 0.1g 100mg 200mg 250mg 500mg 1g 5g 25g 100g

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Brand	Packaging	Price	Product name
aablocks AA007C3L	200mg	$27	2-[[1-[1-[(4-Fluorophenyl)methyl]-1H-benzimidazol-2-yl]-4-piperidinyl]methylamino]-4(3H)-pyrimidinone
aablocks AA007C3L	1g	$56	2-[[1-[1-[(4-Fluorophenyl)methyl]-1H-benzimidazol-2-yl]-4-piperidinyl]methylamino]-4(3H)-pyrimidinone
aablocks AA007C3L	5g	$200	2-[[1-[1-[(4-Fluorophenyl)methyl]-1H-benzimidazol-2-yl]-4-piperidinyl]methylamino]-4(3H)-pyrimidinone
aablocks AA007C3L	25g	$807	2-[[1-[1-[(4-Fluorophenyl)methyl]-1H-benzimidazol-2-yl]-4-piperidinyl]methylamino]-4(3H)-pyrimidinone
AHH API-1754	0.1g	$370	Mizolastine
AK Scientific I520	5g	$241	Mizolastine
AK Scientific J98981	5g	$180	Mizolastine
AK Scientific J10320	100mg	$95	Mizolastine
AK Scientific I520	1g	$62	Mizolastine
AK Scientific J10320	5mg	$22	Mizolastine

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Properties

Melting point	217°
Density	1.34±0.1 g/cm3(Predicted)
storage temp.	Refrigerator
solubility	Chloroform (Slightly, Heated), DMSO, Methanol (Slightly, Heated)
form	Solid
pka	9.73±0.40(Predicted)
color	White
Merck	14,6221
InChI	1S/C24H25FN6O/c1-29(23-26-13-10-22(32)28-23)19-11-14-30(15-12-19)24-27-20-4-2-3-5-21(20)31(24)16-17-6-8-18(25)9-7-17/h2-10,13,19H,11-12,14-16H2,1H3,(H,26,28,32)
InChIKey	PVLJETXTTWAYEW-UHFFFAOYSA-N
SMILES	C1(N(C2CCN(C3N(CC4=CC=C(F)C=C4)C4=CC=CC=C4N=3)CC2)C)=NC=CC(=O)N1

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H302：Harmful if swallowed

H312：Harmful in contact with skin

H332：Harmful if inhaled

Precautionary statements

P261：Avoid breathing dust/fume/gas/mist/vapours/spray.

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P270：Do not eat, drink or smoke when using this product.

P271：Use only outdoors or in a well-ventilated area.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P304+P340：IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312：Call a POISON CENTER or doctor/physician if you feel unwell.

P322：Specific measures (see …on this label).

P330：Rinse mouth.

P363：Wash contaminated clothing before reuse.

P501：Dispose of contents/container to..…

Description

Mizolastine was marketed in Germany and Switzerland as Mizollen for the symptomatic relief of seasonal and perennial allergic rhinoconjunctivitis and urticaria. Mizolastine is a new long-acting, orally active antihistaminic agent with a rapid onset of action ; the two most recent H1 antagonists launched were fexofenadine, metabolite of terfenadine (Sepracor, 1996) and Olopatadine (Kyowa Hakko, 1997). Mizolastine can be prepared in 2 steps from 2-chloro 1- (4-fluorobenzyl)benzimidazole by successive condensations of appropriate amine and thioether. Mizolastine selectively blocks the peripheral H1 receptors (but not the serotonergic, noradrenergic, muscarinic receptors) with a minimal occupancy of brain receptors, and therefore does not elicit any sedative effects. Moreover, Mizolastine does not produce cardiac rhythm disorders which have been associated with certain non-sedating antihistamines in humans.

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Suppliers and manufacturers

Henan Bao Enluo International TradeCo.，LTD

$100.00

Mizolastine

CAS:108612-45-9
Hebei Yanxi Chemical Co., Ltd.

Mizolastine

CAS:108612-45-9
TargetMol Chemicals Inc.

$30.00

Mizolastine

CAS:108612-45-9
Longyan Tianhua Biological Technology Co., Ltd

$8.00

Mizolastine

CAS:108612-45-9
Dideu Industries Group Limited

$1.10

Mizolastine USP/EP/BP

CAS:108612-45-9
Henan Tianfu Chemical Co.,Ltd.
Xiamen AmoyChem Co., Ltd
CONIER CHEM AND PHARMA LIMITED
HANGZHOU CLAP TECHNOLOGY CO.,LTD
AFINE CHEMICALS LIMITED

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