insoluble in H2O; insoluble in EtOH; ≥2.18 mg/mL in DMSO with gentle warming and ultrasonic
form
A crystalline solid
color
Light yellow to yellow
Description
MRT68921 is an inhibitor of ULK1 and ULK2 (IC50s = 2.9 and 1.1 nM, respectively). Through its effects on ULK1, MRT68921 blocks autophagy in cells, driving the accumulation of stalled early autophagosomal structures.
