MP-A08

$33 - $1802

Product nameMP-A08
Cas No219832-49-2
MFC27H25N3O4S2
MW519.64

Synonyms

MP-A08;Benzenesulfonamide, 4-methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]-;4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide;4-Methyl-N-(2-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)phenyl)benzenesulfonamide;MPA08,SphK,Sphingosine kinase,MP-A-08,inhibit,Inhibitor,MP-A08,MP A08;4-Methyl-N-(2-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)phenyl)benzenesulfonamide , MP-A08

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Price

23 prices

Brand less more

Cayman Chemical Crysdot Tocris TRC Biorbyt Ltd AK Scientific ChemScene DC Chemicals
Package less more

10 1mg 5mg 50 10mg 25mg 50mg 100mg

Clear All Done

Brand	Packaging	Price	Product name
AK Scientific 2209CC	25mg	$538	4-Methyl-N-[2-[[2-[(4-methylphenyl)sulfonylamino]phenyl]iminomethyl]phenyl]benzenesulfonamide
Biorbyt Ltd orb611453	5mg	$569.5	MP-A08
Biorbyt Ltd orb611453	10mg	$615.4	MP-A08
Biorbyt Ltd orb611453	50mg	$1802	MP-A08
Cayman Chemical 21903	25mg	$396	MP-A08
Cayman Chemical 21903	1mg	$33	MP-A08
Cayman Chemical 21903	5mg	$96	MP-A08
Cayman Chemical 21903	10mg	$176	MP-A08
ChemScene CS-5681	10mg	$110	MP-A08
ChemScene CS-5681	1mg	$50	MP-A08

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Properties

Boiling point	717.1±70.0 °C(Predicted)
Density	1.28±0.1 g/cm3(Predicted)
solubility	DMF: 33 mg/ml; DMF:PBS(pH7.2) (1:2): 0.3 mg/ml; DMSO: 12 mg/ml
form	A crystalline solid
pka	7.88±0.10(Predicted)
color	Light yellow to yellow

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H315：Causes skin irritation

H319：Causes serious eye irritation

Precautionary statements

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313：IF SKIN irritation occurs: Get medical advice/attention.

P337+P313：IF eye irritation persists: Get medical advice/attention.

Description

MP-A08 is an ATP-competitive inhibitor of sphingosine kinases SPHK1 and SPHK2 (K_is = 27 and 6.9 μM, respectively). It is selective for SPHK1/2 over a panel of 140 human protein kinases at concentrations up to 25 μM. MP-A08 (15 μM) reduces generation of cellular sphingosine-1-phosphate (S1P; ) without inducing degradation of SPHK1 in Jurkat cells. It induces a 3.7-, 3.5-, and 5.8-fold increase in C-18 ceramide , C-20 ceramide , and C20:1-ceramide levels, respectively, and dose-dependently activates the apoptosis-associated p38 and JNK pathways in vitro. MP-A08 reduces proliferation of a variety of human cancer cell lines (EC₅₀s = 8-44.9 μM). MP-A08 also reduces tumor vasculature, as determined by CD31 staining, and volume as well as S1P protein levels in A549 human lung adenocarcinoma xenografts in mice.

Suppliers and manufacturers

TargetMol Chemicals Inc.

$39.00/1mg

MP-A08

CAS:219832-49-2
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Musechem

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