LPA1 (also known as EDG-2) is one of four known LPA receptors (LPA1-4).1 LPA1-3 are part a family of G protein-coupled receptors that share identity to the sphingosine-1-phosphate receptors (S1P1-5).2 LPA1 couples with three types of G proteins, Gi/o, Gq, and G12/13 to induce a range of cellular responses including activation of phospholipase C, multiple kinases, the serum response element and cell proliferation.3,4 LPA1 mRNA is detected a wide range of tissues and cells including brain, heart, small intestine, spleen, testis, kidney, HeLa cells, and A549 cells.5,6 Mouse and human LPA1 have 364 amino acids with an estimated molecular weight of 41 kDa.4 Cayman’s LPA1 Polyclonal Antibody detects the protein from several species from 43-50 kDa, suggesting heterogeneous LPA1 post-translational modifications in distinct cells.WARNING This product is not for human or veterinary use.
