L-165,041

$48 - $2551

Product nameL-165,041
Cas No79558-09-1
MFC22H26O7
MW402.44
MDL NumberMFCD04974501

Synonyms

L-165041, >=98%;2-[4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]-;2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy)phenoxy)acetic acid;Acetic acid, 2-[4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]-;L 1q5041;L-165,041;4-[3-(4-ACETYL-3-HYDROXY-2-PROPYLPHENOXY)PROPOXY]PHENOXYACETIC ACID;4-[3-(2-PROPYL-3-HYDROXY-4-ACETYL)PHENOXY]PROPYLOXYPHENOXY-ACETIC ACID

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Price

65 prices

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Sigma-Aldrich Cayman Chemical Arctom ACHEMBLOCK aablocks Tocris TRC Usbiological Biorbyt Ltd ApexBio Technology Matrix Scientific AK Scientific ChemScene American Custom Chemicals Corporation Ambeed DC Chemicals
Package less more

100mg 250mg 5mg 1mlx10mm(indmso) 10mm(in1mldmso) 2mg 10mg 25mg 50mg 50 10mm*1mlindmso(solid+solvent) 1g 10mm*1mlindmso(solution) 10 250.00mg

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Brand	Packaging	Price	Product name
aablocks AA008LU7	5mg	$52	L-165,041
aablocks AA008LU7	10mg	$72	L-165,041
aablocks AA008LU7	25mg	$124	L-165,041
aablocks AA008LU7	50mg	$198	L-165,041
aablocks AA008LU7	100mg	$304	L-165,041
ACHEMBLOCK O32757	1G	$1200	2-(4-(3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy)phenoxy)acetic acid
ACHEMBLOCK O32757	100MG	$240	2-(4-(3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy)phenoxy)acetic acid
AK Scientific X6845	250mg	$2551	2-(4-(3-(4-Acetyl-3-hydroxy-2-propylphenoxy)-propoxy)phenoxy)aceticacid
Ambeed A101739	50mg	$335	L-165041
Ambeed A101739	100mg	$534	L-165041

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Properties

Melting point	127-128 °C(lit.)
Boiling point	600.8±55.0 °C(Predicted)
Density	1.222±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: >10 mg/mL
form	solid
pka	3.23±0.10(Predicted)
color	off-white
Stability	Light Sensitive
InChI	1S/C22H26O7/c1-3-5-19-20(11-10-18(15(2)23)22(19)26)28-13-4-12-27-16-6-8-17(9-7-16)29-14-21(24)25/h6-11,26H,3-5,12-14H2,1-2H3,(H,24,25)
InChIKey	HBBVCKCCQCQCTJ-UHFFFAOYSA-N
SMILES	CCCc1c(O)c(ccc1OCCCOc2ccc(OCC(O)=O)cc2)C(C)=O

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H302：Harmful if swallowed

H315：Causes skin irritation

H319：Causes serious eye irritation

H335：May cause respiratory irritation

Precautionary statements

P261：Avoid breathing dust/fume/gas/mist/vapours/spray.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

L-165041 is a cell permeable PPARβ (peroxisome proliferator-activated receptor β) agonist which induces adipocyte differentiation in NIH-PPARβ cells. In addition, this ligand reduces lipid accumulation in the liver and decreases total hepatic cholesterol and triglyceride content. Studies suggest that L-165041 affects mRNA expression by reducing the expression of PPARγ, apolipoprotein B, interleukin 1 β (IL-1β), and interleukin-6, while increasing the expression of PPARβ, lipoprotein lipase (LPL), and ATP-binding cassette transporter G1 (ABCG1). Furthermore, upon binding to PPARβ L-165041 suppresses vascular smooth muscle proliferation and migration by inhibiting the cell cycle, specifically blocking G₁ to S phase progression and repressing the phosphorylation of retinoblastoma protein (Rb) in rats. Alternate studies suggest that L-165041 suppresses the cytokine-induced expression of VCAM-1 (vascular cell adhesion molecule-1) and increases UCP3 (uncoupling protein 3) gene expression in L6 myotubes. L-165041 is an activator of PPAR beta.

Related product price

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Suppliers and manufacturers

career henan chemical co

$1.00

L-165,041

CAS:79558-09-1
TargetMol Chemicals Inc.

$40.00

L-165041

CAS:79558-09-1
Capot Chemical Co.,Ltd.
HANGZHOU LEAP CHEM CO., LTD.
TargetMol Chemicals Inc.
DAYANG CHEM (HANGZHOU) CO.,LTD
Amadis Chemical Company Limited
ChemShuttle, Inc.
BOC Sciences
Sigma-Aldrich

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