JTE 013 is an antagonist for EDG (endothelial differential gene 1 receptor). The compound is highly selective for EDG-5, EDG-3 and EDG-6. JTE 013 inhibits S1P binding to human EDG-5 with an IC50 value of 17.6 nM. At concentrations up to 10 μM, displays 4.2% inhibition of EDG-3 and does not antagonize EDG-1.
