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ChemicalBook > CAS DataBase List > IPI 145

IPI 145

  • $55 - $2550
  • Product name:IPI 145
  • CAS:1201438-56-3
  • MF: C22H17ClN6O
  • MW:416.86
  • EINECS:200-256-5
  • MDL Number:MFCD15144635
  • Synonyms:IPI145; IPI 145; IPI-145. INK-1197; INK 1197; INK1197;DUVELISIB (IPI-145; INK1197);CS-680;8-chloro-2-phenyl-3-[(1s)-1-(7h-purin-6-ylamino)ethyl]isoquinolin-1-one;IPI-145 (Duvelisib, INK1197);IPI-145;IPI-145 (INK-1197);IPI-145 INK197;8-Chloro-2-phenyl-3-[(1S)-1-(9H-purin-6-ylamino)ethyl]-1(2H)-isoquinolinone
Price
  • Brand:DC Chemicals
  • Product number:DC5072
  • Product nameDuvelisib(IPI-145,INK1197)
  • Purity:>98%
  • Packaging:250 mg
  • Price:$700
  • Updated:2021/12/16 17:17:49
  • Buy:Buy
  • Brand:DC Chemicals
  • Product number:DC5072
  • Product nameDuvelisib(IPI-145,INK1197)
  • Purity:>98%
  • Packaging:1 g
  • Price:$1500
  • Updated:2021/12/16 17:17:49
  • Buy:Buy
  • Brand:Medical Isotopes, Inc.
  • Product number:46882
  • Product nameIPI145
  • Purity:
  • Packaging:5 mg
  • Price:$650
  • Updated:2021/12/16 17:17:49
  • Buy:Buy
  • Brand:TRC
  • Product number:I739400
  • Product nameIPI145
  • Purity:
  • Packaging:50mg
  • Price:$225
  • Updated:2021/12/16 17:17:49
  • Buy:Buy
  • Brand:Usbiological
  • Product number:474116
  • Product nameIPI-145
  • Purity:
  • Packaging:100mg
  • Price:$1168
  • Updated:2021/12/16 17:17:49
  • Buy:Buy
Properties
  • Boiling point:757.8±60.0 °C(Predicted)
  • Density 1.474±0.06 g/cm3(Predicted)
  • pka10.05±0.10(Predicted)
  • form White solid.
Safety Information
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Description

IPI-145 is a potent inhibitor of the phosphoinositide 3-kinase (PI3K) isoforms PI3Kγ and PI3Kδ (IC50s = 0.24 and 50 nM, respectively). It is orally bioavailable and selective. As PI3Kγ and PI3Kδ are preferentially expressed in immune cells, IPI-145 has profound effects in collagen-induced and adjuvant-induced arthritis, ovalbumin-induced asthma, and systemic lupus erythematosus animal models. It also has potential applications in immunotherapy and in certain cancers.


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