GSK J4 HCl

$12 - $1962

Product nameGSK J4 HCl
Cas No1373423-53-0
MFC24H27N5O2
MW417.5
MDL NumberMFCD22683852

Synonyms

GSK J4;N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine ethyl ester;GSK J4 HCl;N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyriMidinyl]-|-alanine ethyl ester;β-Alanine, N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-, ethyl ester, hydrochloride (1:1);Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate;Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)prop;Histone Lysine Demethylase Inhibitor VIII, GSK-J4

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Price

44 prices

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aablocks AvaChem ApexBio Technology Arctom Axon Medchem Sigma-Aldrich ChemScene TRC ACHEMBLOCK DC Chemicals Synthonix Crysdot Tocris
Package less more

25mg 2x25mg 10mm*1mlindmso 50 1mg 5mg 10mg 1g 10mm*1mlindmso(solid+solvent) 500mg 10mm*1mlindmso(solution) 50mg 100mg 250mg

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Brand	Packaging	Price	Product name
aablocks AA009C9F	1mg	$12	Gsk J4 Hcl
aablocks AA009C9F	5mg	$28	Gsk J4 Hcl
aablocks AA009C9F	10mg	$44	Gsk J4 Hcl
aablocks AA009C9F	250mg	$511	Gsk J4 Hcl
aablocks AA009C9F	500mg	$773	Gsk J4 Hcl
aablocks AA009C9F	1g	$1175	Gsk J4 Hcl
ACHEMBLOCK X212247	100MG	$340	GSK-J4
ACHEMBLOCK X212247	50MG	$205	GSK-J4
ApexBio Technology A4190	10mg	$110	GSKJ4HCl
ApexBio Technology B5959	10mg	$95	GSK J4 free base

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Properties

Boiling point	581.2±50.0 °C(Predicted)
Density	1.216±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: soluble20mg/mL, clear
pka	5.95±0.10(Predicted)
form	Tan semi-solid
color	white to beige
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI	1S/C24H27N5O2/c1-2-31-23(30)10-14-26-21-17-22(28-24(27-21)20-9-5-6-13-25-20)29-15-11-18-7-3-4-8-19(18)12-16-29/h3-9,13,17H,2,10-12,14-16H2,1H3,(H,26,27,28)
InChIKey	WBKCKEHGXNWYMO-UHFFFAOYSA-N
SMILES	O=C(OCC)CCNC1=CC(N2CCC(C=CC=C3)=C3CC2)=NC(C4=CC=CC=N4)=N1

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H315：Causes skin irritation

H319：Causes serious eye irritation

H335：May cause respiratory irritation

Precautionary statements

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321：Specific treatment (see … on this label).

P332+P313：IF SKIN irritation occurs: Get medical advice/attention.

P362：Take off contaminated clothing and wash before reuse.

Description

GSK-J4 (1373423-53-0) is a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release). Cell permeable, ethyl ester of GSK J1 (cat.# 10-1393).1 GSK-J4 rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies.2

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Suppliers and manufacturers

career henan chemical co

$1.00/1KG

ethyl 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoate

CAS:1373423-53-0
TargetMol Chemicals Inc.

$51.00/2mg

GSK-J4

CAS:1373423-53-0
ATK CHEMICAL COMPANY LIMITED
Biochempartner
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Dideu Industries Group Limited
Chemia Biotechnology（Shanghai） Co., Ltd
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
Nantong HI-FUTURE Biology Co., Ltd.

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