Fexinidazole is an antiparasitic drug that, in different preparations, is effective against trypanosomes. It is orally available and rapidly metabolized to two active metabolites, a sulfone and a sulfoxide. Fexinidazole has been shown to kill both T. brucei gambiense and T. brucei rhodesiense in animal studies and is being tested for use in human African trypanosomiasis.
