COX-2 Inhibitor V, FK3311 is a cell-permeable and orally available sulfonanilide that acts as a selective Cox-2 inhibitor and NSAID. COX-2 Inhibitor V, FK3311 has been shown to exhibit 500-fold greater potency in inhibiting the LPS-induced (IC50 = 316 nM in human mononuclear cells) than the non-induced/constitutive (IC50 = 160 μM in human platelets) TxB2 production in vitro and effectively alleviate warm ischemia-reperfusion injury in the canine liver and rat lung.
