Soluble in water, sparingly soluble in anhydrous ethanol, very slightly soluble in acetone.
Merck
14,3557
Safety Information
Symbol(GHS)
Signal word
Warning
Hazard statements
H302：Harmful if swallowed
Precautionary statements
P264：Wash hands thoroughly after handling.
P264：Wash skin thouroughly after handling.
P270：Do not eat, drink or smoke when using this product.
P501：Dispose of contents/container to..…
Description
Emedastine difumarate, a potent H1-receptor antagonist, was launched in Japan for the
treatment of allergic rhinitis and urticaria. Emedastine exerts its antiallergic effect via
inhibition of substance P-induced histamine release. It has been demonstrated both in vitro
and in vivo that this effect is mediated by the inhibition of Ca2+release from extracellular
stores and of Ca2+ influx into mast cells. In a clinical trial with bronchial asthma, emedastine
improved asthmatic symptoms in 55.3% of patients.
