P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
Description
Dabigatran is a potent thrombin inhibitor (Ki = 4.5 nM). It also inhibits trypsin (Ki = 50.3 nM), but only weakly inhibits other serine proteases. Dabigatran has poor bioavailability after oral administration. However, dabigatran etexilate is a double prodrug that has excellent oral bioavailability and undergoes in vivo hydrolytic cleavage to produce dabigatran.