Cefotetan is comparatively stable, lasting for approximately 24 hours at room temperature when
reconstituted. Slight yellowing and slight darkening produce materials that are still acceptable for therapy.
Cefotetan is chemically incompatible with tetracycline, aminoglycosides, and with heparin, often forming
precipitates with them. With respect to its molecular mode of action, it has a special affinity for PBP-3 of
Gram-negative bacteria, consequently producing filamentous forms. It also binds well with PBP-1A and -1B,therefore leading to cell lysis and death. Whereas it is stable to a wide range of β-lactamases, it also is a
potent inducer in some bacteria.
