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ChemicalBook CAS DataBase List Cabazitaxel

Cabazitaxel

$29 - $3980

Product nameCabazitaxel
Cas No183133-96-2
MFC45H57NO14
MW835.93
EINECS680-632-7
MDL NumberMFCD18827611

Synonyms

(2AR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-;TXD-258;(αR,βS)-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxybenzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-diMethoxy-4a,8,13,13-tetraMethyl-5-oxo-7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester;XRP 6258;Cabazitaxel;β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxybenzenepropanoic Acid [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-12b-(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-diMethoxy-4a,8,13,13-tetraMethyl;7β, 10β-DiMethoxydocetaxel;Cabazitaxel(XRP-6258)

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Price

64 prices

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TCI Chemical Sigma-Aldrich Cayman Chemical CSNpharm JR MediChem Arctom Chemenu Crysdot AvaChem TRC Biorbyt Ltd ApexBio Technology Frontier Specialty Chemicals AK Scientific Medical Isotopes, Inc. Chem-Impex BroadPharm ChemScene American Custom Chemicals Corporation Biosynth Carbosynth DC Chemicals
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Brand	Packaging	Price	Product name
AK Scientific X7252	1mg	$29	Cabazitaxel
AK Scientific X7252	500mg	$879	Cabazitaxel
American Custom Chemicals Corporation API0005344	5MG	$847	CABAZITAXEL
American Custom Chemicals Corporation API0005344	50MG	$2425.5	CABAZITAXEL
ApexBio Technology B2157	5mg	$50	Cabazitaxel
ApexBio Technology B2157	10mM(in1mLDMSO)	$61	Cabazitaxel
ApexBio Technology B2157	10mg	$64	Cabazitaxel
ApexBio Technology B2157	25mg	$84	Cabazitaxel
ApexBio Technology B2157	50mg	$103	Cabazitaxel
ApexBio Technology B2157	100mg	$194	Cabazitaxel

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Properties

Melting point	180 °C
Boiling point	870.7±65.0 °C(Predicted)
Density	1.31
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form	White solid.
pka	11.20±0.46(Predicted)
color	White to Off-White
optical activity	[α]/D -36 to -44°, c =0.5 in methanol
InChIKey	BMQGVNUXMIRLCK-JACFBOAKNA-N

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H302：Harmful if swallowed

H315：Causes skin irritation

H341：Suspected of causing genetic defects

H373：May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P202：Do not handle until all safety precautions have been read and understood.

P260：Do not breathe dust/fume/gas/mist/vapours/spray.

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P308+P313：IF exposed or concerned: Get medical advice/attention.

Description

In June 2010, the U.S. FDA approved cabazitaxel (also referred to as XRP6258 and RPR 116258A) in combination with the steroid prednisone for the treatment of metastatic Castration-Resistant Prostate Cancer (mCRPC) for patients who were previously treated with a docetaxelcontaining regimen for late-stage disease.
Cabazitaxel is a semisynthetic analog of the natural product taxol, which is isolated from the bark of the yew tree. Cabazitaxel is a microtubule inhibitor that binds to the taxol-binding site of tubulin. Similar to other tubulin inhibitors of the taxol class, cabazitaxel inhibits microtubule disassembly resulting in mitotic blockade and cell death. Docetaxel, also a semisynthetic taxol analog, was approved by the FDA for the treatment of mCRPC in 2004. However, docetaxel is a substrate for P-gp, which is thought to contribute to the constitutive and acquired resistance of cancer cells to taxanes. Cabazitaxel has poor affinity for P-gp and showed antitumor activity in preclinical in vitro studies and in vivo tumor models that overexpress this protein. Cabazitaxel is synthesized on a commercial scale from 10-deacetylbaccatin .

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Suppliers and manufacturers

RongNa Biotechnology Co.,Ltd

$1.00/1g

Cabazitaxel

CAS:183133-96-2
Changzhou Rokechem Technology Co., Ltd.

$0.00/1Kg

Cabazitaxel

CAS:183133-96-2
Henan Bao Enluo International TradeCo.，LTD

$50.00/1kg

Cabazitaxel

CAS:183133-96-2
Hangzhou ICH Biofarm Co., Ltd

$0.00/1kg

Cabazitaxel

CAS:183133-96-2
Shaanxi Haibo Biotechnology Co., Ltd

$0.00/25kg

Cabazitaxel

CAS:183133-96-2
Shaanxi TNJONE Pharmaceutical Co., Ltd

$0.00/1kg

Cabazitaxel

CAS:183133-96-2
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

$0.00/1g

Cabazitaxel

CAS:183133-96-2
Wuhan JiyunZen Tech Co., Ltd.

$0.50/KG

Cabazitaxel

CAS:183133-96-2
SICHUAN XIELI PHARMACEUTICAL CO.,LTD.
Protheragen-ING

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