CYCLOPAMINE

$14 - $2329

Product nameCYCLOPAMINE
Cas No4449-51-8
MFC27H41NO2
MW411.62
MDL NumberMFCD09878269

Synonyms

11-DEOXOJERVINE;CyclopaMine, froM VeratruM californiciM;CYCLOPAMINE;Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol,1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3',6',10,11b-tetraMethyl-,(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-;Cyclopamine 11-Deoxojervine (3b,23b)-17,23-Epoxy-11-deoxoveratraman-3-ol;Cyclopamine, >=98%;(3S,6AS,6bS,8aR,10S,12aS,13S,13aS,15aS,15bR)-10,13,14,15b-tetramethyl-1,2,3,4,6,6a,6b,7,7a,8a;11-DEOXYJERVINE

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Price

143 prices

Brand less more

aablocks Cayman Chemical Adipogen Life Sciences Arctom ApexBio Technology ChemScene CSNpharm AvaChem AK Scientific Apolloscientific Biosynth Biorbyt Ltd DC Chemicals Matrix Scientific Chemenu Tocris Sigma-Aldrich ACHEMBLOCK Usbiological Crysdot American Custom Chemicals Corporation Medical Isotopes, Inc.
Package less more

5mg 0.01g 10mm*1mlindmso 1mg 1unit 1 0.1g 200mg 250mg 0.25g 500mg 0.5g 1g evaluationsample 20mg 50mg 100mg 10mm(in1mldmso) 10mg 25mg 0.025g

Clear All Done

Brand	Packaging	Price	Product name
aablocks AA00D7XW	1mg	$14	Cyclopamine
aablocks AA00D7XW	5mg	$33	Cyclopamine
aablocks AA00D7XW	10mg	$52	Cyclopamine
aablocks AA00D7XW	25mg	$96	Cyclopamine
aablocks AA00D7XW	100mg	$306	Cyclopamine
ACHEMBLOCK V155924	50MG	$245	Cyclopamine
ACHEMBLOCK V155924	100MG	$395	Cyclopamine
Adipogen Life Sciences AG-CN2-0028-M005	5mg	$60	Cyclopamine
Adipogen Life Sciences AG-CN2-0028-M005	5mg	$50	Cyclopamine
Adipogen Life Sciences AG-CN2-0028-M001	1mg	$25	Cyclopamine

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Properties

Melting point	236-238°C
Boiling point	531.29°C (rough estimate)
Density	1.0274 (rough estimate)
refractive index	1.6400 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO: soluble
form	solid
pka	15.05±0.70(Predicted)
color	White
Stability	Store in Freezer at - 20°C
InChIKey	QASFUMOKHFSJGL-LAFRSMQTSA-N
SMILES	C1C2[C@@]([H])(CC[C@@]3([C@H](C)[C@]4([H])NC[C@@H](C)C[C@@]4([H])O3)C=2C)[C@@]2([H])[C@@]1([H])[C@@]1(C)CC[C@H](O)CC1=CC2

Safety Information

Symbol(GHS)

Signal word

Danger

Hazard statements

H301：Toxic if swalloed

Precautionary statements

P202：Do not handle until all safety precautions have been read and understood.

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P270：Do not eat, drink or smoke when using this product.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310：IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405：Store locked up.

Description

Cyclopamine is a natural steroidal alkaloid that inhibits signaling through the hedgehog pathway at the level of the pathway activator Smoothened. By altering gene expression in this signaling sequence, cyclopamine induces defects in morphogenesis, first observed in chicks and sheep as cyclopia. As a readout of action, cyclopamine inhibits hedgehog-dependent expression of Pax7 with an IC50 value of 24 nM. Although teratogenic during development, cyclopamine has potential applications in the treatment of cancer.

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Suppliers and manufacturers

career henan chemical co

$2.00

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