JARID1B/PLU1 (C-Term) Polyclonal Antibody

Jumonji AT rich interactive domain 1B (JARID1B) nuclear proteins are potential histone demethylases.1,2 JARID1B demethylation of Lys-4 of histone H3 plays an important role in breast cancer cell proliferation through BRCA1 repression.1 JARID1B acts as a transcriptional co-repressor of two developmental transcription factors, PAX-9 and BF1, which are crucial for organogenesis in mouse embryo.3 JARID1B has also been shown to interact directly with histone deacetylase.4WARNING This product is not for human or veterinary use.