HIF-1α (C-Term) Polyclonal Antibody

Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that accumulates under low-oxygen conditions.1,2 Following hypoxic stimulus and cytoplasmic accumulation, HIF-1α migrates to the nucleus where with other transcription factors, it drives the production of stress-adaptive proteins. This response is essential for maintenance of normal oxidative physiology, however overexpression in cancer cells promotes tumor survival.2,3,4,5,6 HIF-1α is an endothelial PAS domain protein 1 (EPAS-1) family member with phosphorylation dependent activities.7,8 Cayman Chemical’s HIF-1α polyclonal antibody can be used for WB analysis for HIF-1α on samples from human, mouse, and simian. It is not suitable for ICC or IP. Other applications for use of this antibody have not yet been tested.WARNING This product is not for human or veterinary use.