NF-κB (p50) (human recombinant)

The NF-κB/Rel family of transcription factors is comprised of several structurally-related proteins that form homodimers and heterodimers and include p50/p105, p52/p100, RelA (p65), and c-Rel/NF-κB 1. Members of this family are responsible for regulating over 150 target genes, including the expression of inflammatory cytokines, chemokines, immunoreceptors, and cell adhesion molecules. Because of this, NF-κB has often been called a 'central mediator of the human immune response.2 Acting as dimers, these transcription factors bind to 10 base pair DNA sequences, collectively called κB sites thereby regulating expression of target genes. The most common Rel/NF-κB dimer in mammals contains (p50)-RelA (p50/p65) heterodimers and is called NF-κB. The importance of Rel/NF-κB transcription factors in human inflammation and certain diseases makes them attractive targets for potential therapeutics.3,4,5WARNING This product is not for human or veterinary use.