Endocannabinoids, such as arachidonoyl ethanolamide (AEA) and 2-arachidonoyl glycerol (2-AG), function as short-range modulators of cell and synaptic activity. Monoacylglycerol lipase (MAGL) hydrolyzes 2-AG to terminate its biological actions and works consecutively with hormone-sensitive lipase to mobilize fatty acids from the triglyceride stores of adipocytes.1,2 MAGL has a molecular weight of ~33 kDa and exhibits a high degree of homology among human, murine, and rat at the amino acid level.1,2,3,4 The enzyme is expressed in a variety of tissues with most abundant expression in skeletal muscle and adipose tissue, suggesting a role of MAGL in monoglyceride hydrolysis in diverse tissues. Cayman’s MAGL (FL) Polyclonal Antibody can be used for Western blot, immunocytochemistry, and immunohistochemistry analysis for MAGL.WARNING This product is not for human or veterinary use.
