EP2 Receptor Polyclonal Antibody

The biological effects of prostaglandin E2 (PGE2) are mediated through interaction with four distinct membrane-bound G-protein coupled EP receptors: EP1, EP2, EP3, and EP4.1,2 Binding of PGE2 to the EP2 receptor results in an increase in adenylate cyclase activity with a subsequent increase in cAMP.3,4 Pharmacologicially, EP2 receptors mediate relaxation of smooth muscle and are distinguished from EP4 receptors by their sensitivity to the EP2 receptor selective agonist butaprost.1,2,3 The human EP2 receptor is comprised of 358 amino acids with a molecular mass of approximately 40,000.3 EP2 is detected on immunoblot at 65 or 52 kDa depending on the degree of post-translational modifications of that receptor. mRNA for the EP2 receptor is expressed in a variety of tissues including lung, placenta, spleen, intestine, kidney, and sensory neuron.3,4,5WARNING This product is not for human or veterinary use.