ent-8-iso-Prostaglandin F2α-d9 (ent-8-iso-PGF2α-d9) is intended for use as an internal standard for the quantification of ent-8-iso-PGF2α (Item No. 10011545) by GC- or LC-mass spectrometry. Isoprostanes are produced by the non-enzymatic, free-radical peroxidation of arachidonic acid. They have been used as biomarkers of oxidative stress, but they also have been found to have a potent biological activity. ent-8-iso PGF2α is a potent vasoconstrictor of porcine retinal and brain microvessels with EC50 values of 31 and 54 nM, respectively.1WARNING This product is not for human or veterinary use.
