Isoprostanes are produced by the non-enzymatic, free radical peroxidation of arachidonic acid. They have been used as biomarkers of oxidative stress, but also have been found to have a potent biological activity.
ent-8-
iso Prostaglandin F
2α (
ent-8-
iso PGF
2α) is a potent vasoconstrictor of porcine retinal and brain microvessels with EC
50 values of 31 and 54 nM, respectively.
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