Description
Isoprostanes are produced by the non-enzymatic, free radical peroxidation of arachidonic acid. They have been used as biomarkers of oxidative stress, but also have been found to have a potent biological activity.
ent-8-
iso Prostaglandin F
2α (
ent-8-
iso PGF
2α) is a potent vasoconstrictor of porcine retinal and brain microvessels with EC
50 values of 31 and 54 nM, respectively.
1
References
1. Hou, X., Robers, L.J., II, Gobeil, F., Jr., et al.
Isomer-specific contractile effects of a series of synthetic F2-isoprostanes on retinal and cerebral microvasculature Free Radic. Biol. Med. 36(2),163-172(2004).