5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[[4-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarboxamide is a potent benzimidazole analog that inhibits IKK-ε with an IC50 value of ~15.8 μM (1), where IKK-ε is mostly expressed n immune cells and thought to play a role in immune response.