CGRP is a vasodilative neuropeptide synthesized mainly
in the central nervous system. It is a transmitter of nociceptive signals in relation to migraines. The presence of CGRP-α (or αCGRP) mRNA formed
by alternative splicing from the calcitonin gene
(CALCA) was reported in 1982, and it was isolated in
1984 from human medullary thyroid calcinoma. CGRP-β (or βCGRP) was identified by human genome
analysis in 1985.
