Astemizole

$39 - $1015

Product nameAstemizole
Cas No68844-77-9
MFC28H31FN4O
MW458.57
EINECS272-441-9
MDL NumberMFCD00153919

Synonyms

1-((4-fluorophenyl)methyl)-n-(1-(2-(4-methoxyphenyl)ethyl)-4-piperidinyl)-1h-b ;r45312 ;retolen ;ASTEMIZOLE;1-[(4-FLUOROPHENYL)METHYL]-N-[1-[2-(4-METHOXYPHENYL)ETHYL]-4-PIPERIDINYL]-1H-BENZIMIDAZOL-2-AMINE;(1-[4-FLUOROBENZYL]-2-[1-(4-METHOXYPHENETHYL)PIPERIDIN-4-YL] AMINOBENZIMIDAZOLE;Astemisan;R 43512

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Price

25 prices

Brand less more

Sigma-Aldrich Cayman Chemical AvaChem Tocris TRC ApexBio Technology AK Scientific Medical Isotopes, Inc. Oakwood ChemScene American Custom Chemicals Corporation Biosynth Carbosynth DC Chemicals
Package less more

5mg 10mg 25mg 50mg 50 100mg 250mg 1g

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Brand	Packaging	Price	Product name
AK Scientific K146	10mg	$104	Astemizole
American Custom Chemicals Corporation API0002918	10MG	$165.9	ASTEMIZOLE
American Custom Chemicals Corporation API0002918	25MG	$704.55	ASTEMIZOLE
ApexBio Technology B7409	100mg	$140	Astemizole
AvaChem 3753	100mg	$139	Astemizole
AvaChem 3753	10mg	$39	Astemizole
AvaChem 3753	25mg	$59	Astemizole
Biosynth Carbosynth FA18002	25mg	$75	Astemizole
Biosynth Carbosynth FA18002	10mg	$41	Astemizole
Biosynth Carbosynth FA18002	50mg	$99	Astemizole

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Properties

Melting point	172.9°C
Boiling point	627.3±65.0 °C(Predicted)
Density	1.1587 (estimate)
storage temp.	2-8°C
solubility	DMSO: >20mg/mL
pka	pKa 4.85(H2O t=25.0 I=0.025) (Uncertain);8.69(H2O t=25.0 I=0.025) (Uncertain)
form	powder
color	Crystals
Water Solubility	It is soluble in DMSO (25 mg/ml ), ethanol (25 mg/ml), chloroform, methanol, and water (partly miscible).
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H315：Causes skin irritation

H319：Causes serious eye irritation

H335：May cause respiratory irritation

Precautionary statements

P261：Avoid breathing dust/fume/gas/mist/vapours/spray.

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P271：Use only outdoors or in a well-ventilated area.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Astemizole is a non-sedating antihistamine that antagonizes the histamine H1 receptor with a Ki value of 4.4 nM. It is considerably less potent at muscarinic acetylcholine receptors (Ki = 2.4 μM). Astemizole is also a potent blocker of ether-a-go-go-related gene (ERG) potassium channels (IC50 = ~1 nM) that has been used to study long QT syndrome type 2. Furthermore, because it can target oncogenic ERG1 and ERG potassium channels, astemizole has been explored as a potential antineoplastic agent for decreasing proliferation of various cancer cells.

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Suppliers and manufacturers

TargetMol Chemicals Inc.

$42.00/5mg

Astemizole

CAS:68844-77-9
Shanghai kingmorn biotechnology Co.,Ltd.

$0.00/1g

Astemizole

CAS:68844-77-9
Henan Tianfu Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
CONIER CHEM AND PHARMA LIMITED
Shaanxi Dideu Medichem Co. Ltd
AFINE CHEMICALS LIMITED
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
HANGZHOU LEAP CHEM CO., LTD.

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