AKTI-1/2

$29 - $2200

Product nameAKTI-1/2
Cas No612847-09-3
MFC34H29N7O
MW551.64
EINECS1592732-453-0
MDL NumberMFCD09026909

Synonyms

1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]guinoxalin-7-yl)phenyl]methyl]4-piperidinyl]-2H-benzimidazol-2-on;1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-γ],guinoxalin-7-yl)phenyl]methyl]4-piperidinyl]-2H-benzimidazol-2-one;1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]guinoxalin-7-yl)phenyl]methyl]4-piperidinyl]-2H-benzimidazol-2-one;1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-2H-benzimidazol-2-one;2H-BenziMidazol-2-one, 1,3-dihydro-1-[1-[[4-(6-phenyl-1H-iMidazo[4,5-g]quinoxalin-7-yl)phenyl]Methyl]-4-piperidinyl]-;AKT inhibitor VIII (AKTI-1/2);1-(1-(4-(6-Phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)benzyl)-piperidin-4-yl)-1H-benzo[d]imidazol-2(;1-(1-(4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)benzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

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Price

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Cayman Chemical aablocks TRC ChemScene ApexBio Technology DC Chemicals ACHEMBLOCK Biosynth American Custom Chemicals Corporation Chem-Impex Sigma-Aldrich TCI Chemical Axon Medchem Usbiological Crysdot Medical Isotopes, Inc. Matrix Scientific AK Scientific
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2.5mg 25mg 50mg 100mg 250mg 1g 10mm*1mlindmso 500μg 1mg 2mg 10mg 10mm(in1mldmso) 5mg

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Brand	Packaging	Price	Product name
aablocks AA00EC9W	1mg	$61	AKT inhibitor VIII
aablocks AA00EC9W	2mg	$69	AKT inhibitor VIII
aablocks AA00EC9W	5mg	$90	AKT inhibitor VIII
aablocks AA00EC9W	10mg	$144	AKT inhibitor VIII
aablocks AA00EC9W	25mg	$243	AKT inhibitor VIII
aablocks AA00EC9W	50mg	$338	AKT inhibitor VIII
aablocks AA00EC9W	100mg	$476	AKT inhibitor VIII
ACHEMBLOCK Y230492	25MG	$330	AKT Inhibitor VIII
ACHEMBLOCK Y230492	100MG	$680	AKT Inhibitor VIII
ACHEMBLOCK Y230492	10MG	$185	AKT Inhibitor VIII

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Properties

Melting point	242-245°C (dec.)
Density	1.350±0.06 g/cm3(Predicted)
storage temp.	Refrigerator
solubility	insoluble in H2O; insoluble in EtOH; ≥9.2 mg/mL in DMSO
form	Yellow solid
pka	7.49±0.50(Predicted)
color	White to Yellow to Orange
InChIKey	BIWGYFZAEWGBAL-UHFFFAOYSA-N
SMILES	N6(CCC(CC6)[n]7c8c(nc7O)cccc8)Cc1ccc(cc1)c2nc3c(nc2c5ccccc5)cc4[nH]cnc4c3
CAS DataBase Reference	612847-09-3

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H302：Harmful if swallowed

H315：Causes skin irritation

H319：Causes serious eye irritation

H335：May cause respiratory irritation

Precautionary statements

P261：Avoid breathing dust/fume/gas/mist/vapours/spray.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Three related forms of the kinase Akt (1, 2, 3, also known as protein kinase B isoforms PKBα, β, γ) modulate cell proliferation, metabolism, and survival as well as angiogenesis. Akt inhibitor VIII is a potent allosteric inhibitor of Akt1 and Akt2 (IC50s = 58 and 210 nM, respectively) that less effectively blocks Akt3 activity (IC50 = 2.2 μM). It is a poor or ineffective inhibitor of a wide range of other serine-threonine kinases. Akt inhibitor VIII is cell permeable, blocking insulin regulation of forkhead box 01 activity at 1 μM in rat hepatoma cells.

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Suppliers and manufacturers

career henan chemical co

$2.00

AKTI-1/2

CAS:612847-09-3
TargetMol Chemicals Inc.

$61.00

AKT inhibitor VIII

CAS:612847-09-3
ATK CHEMICAL COMPANY LIMITED
Jinan Carbotang Biotech Co.,Ltd.
CONIER CHEM AND PHARMA LIMITED
BOC Sciences
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
Nantong HI-FUTURE Biology Co., Ltd.
TargetMol Chemicals Inc.

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AKTI-1/2
1,3-DIHYDRO-1-(1-((4-(6-PHENYL-1H-IMIDAZO[4,5-G]QUINOXALIN-7-YL)PHENYL)METHYL)-4-PIPERIDINYL)-2H-BENZIMIDAZOL-2-ONE TRIFLUOROACETATE SALT HYDRATE

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