AKTI-1/2

$29 - $2200

Product nameAKTI-1/2
Cas No612847-09-3
MFC34H29N7O
MW551.64
EINECS1592732-453-0
MDL NumberMFCD09026909

Synonyms

1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]guinoxalin-7-yl)phenyl]methyl]4-piperidinyl]-2H-benzimidazol-2-on;1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-γ],guinoxalin-7-yl)phenyl]methyl]4-piperidinyl]-2H-benzimidazol-2-one;1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]guinoxalin-7-yl)phenyl]methyl]4-piperidinyl]-2H-benzimidazol-2-one;1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-2H-benzimidazol-2-one;2H-BenziMidazol-2-one, 1,3-dihydro-1-[1-[[4-(6-phenyl-1H-iMidazo[4,5-g]quinoxalin-7-yl)phenyl]Methyl]-4-piperidinyl]-;AKT inhibitor VIII (AKTI-1/2);1-(1-(4-(6-Phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)benzyl)-piperidin-4-yl)-1H-benzo[d]imidazol-2(;1-(1-(4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)benzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

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Price

47 prices

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TCI Chemical Sigma-Aldrich Cayman Chemical Crysdot TRC Usbiological ApexBio Technology Matrix Scientific AK Scientific Axon Medchem Medical Isotopes, Inc. Chem-Impex ChemScene American Custom Chemicals Corporation Biosynth Carbosynth DC Chemicals
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500μg 1mg 2mg 10mm(in1mldmso) 2.5mg 5mg 10mg 25mg 50mg 100mg 250mg 1g

Clear All Done

Brand	Packaging	Price	Product name
AK Scientific X2144	250mg	$1454	AKT Inhibitor VIII
American Custom Chemicals Corporation INB0000362	25MG	$1963.5	AKTI-1/2 INHIBITOR
American Custom Chemicals Corporation INB0000362	1MG	$240.45	AKTI-1/2 INHIBITOR
American Custom Chemicals Corporation INB0000362	2.5MG	$715	AKTI-1/2 INHIBITOR
ApexBio Technology A3149	25mg	$350	AKT Inhibitor VIII
ApexBio Technology A3149	25mg	$385	AKT inhibitor VIII
ApexBio Technology A3149	10mg	$145	AKT Inhibitor VIII
ApexBio Technology A3149	10mg	$160	AKT inhibitor VIII
ApexBio Technology A3149	10mM(in1mLDMSO)	$165	AKT inhibitor VIII
ApexBio Technology A3149	10mM(in 1mL DMSO)	$130	AKT Inhibitor VIII

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Properties

Melting point	242-245°C (dec.)
Density	1.350±0.06 g/cm3(Predicted)
storage temp.	Refrigerator
solubility	insoluble in H2O; insoluble in EtOH; ≥9.2 mg/mL in DMSO
form	Yellow solid
pka	7.49±0.50(Predicted)
color	White to Yellow to Orange
InChIKey	BIWGYFZAEWGBAL-UHFFFAOYSA-N
SMILES	N6(CCC(CC6)[n]7c8c(nc7O)cccc8)Cc1ccc(cc1)c2nc3c(nc2c5ccccc5)cc4[nH]cnc4c3
CAS DataBase Reference	612847-09-3

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H302：Harmful if swallowed

H315：Causes skin irritation

H319：Causes serious eye irritation

H335：May cause respiratory irritation

Precautionary statements

P261：Avoid breathing dust/fume/gas/mist/vapours/spray.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Three related forms of the kinase Akt (1, 2, 3, also known as protein kinase B isoforms PKBα, β, γ) modulate cell proliferation, metabolism, and survival as well as angiogenesis. Akt inhibitor VIII is a potent allosteric inhibitor of Akt1 and Akt2 (IC50s = 58 and 210 nM, respectively) that less effectively blocks Akt3 activity (IC50 = 2.2 μM). It is a poor or ineffective inhibitor of a wide range of other serine-threonine kinases. Akt inhibitor VIII is cell permeable, blocking insulin regulation of forkhead box 01 activity at 1 μM in rat hepatoma cells.

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Suppliers and manufacturers

career henan chemical co

$2.00/1kg

AKTI-1/2

CAS:612847-09-3
TargetMol Chemicals Inc.

$61.00/2mg

AKT inhibitor VIII

CAS:612847-09-3
ATK CHEMICAL COMPANY LIMITED
Jinan Carbotang Biotech Co.,Ltd.
CONIER CHEM AND PHARMA LIMITED
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
Nantong HI-FUTURE Biology Co., Ltd.
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.

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AKTI-1/2
1,3-DIHYDRO-1-(1-((4-(6-PHENYL-1H-IMIDAZO[4,5-G]QUINOXALIN-7-YL)PHENYL)METHYL)-4-PIPERIDINYL)-2H-BENZIMIDAZOL-2-ONE TRIFLUOROACETATE SALT HYDRATE

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