Human sirtuin 2 (SIRT2) is a NAD+-dependent protein deacetylase with diverse targets, including α-tubulin, phosphoenolpyruvate carboxykinase, and forkhead box protein O1. JFD00244 is an inhibitor of SIRT2 (IC50= 56.7 μM). At 5 μM, JFD00244 induces granulocytic differentiation in the acute promyelocytic leukemia cell line NB4.
![1,4-Bis[(p-hydroxyphenethyl)amino]-anthraquinone](https://www.chemicalbook.com/CAS/GIF/96969-83-4.gif)
