1,2-BIS[(DIMETHYLAMINO)DIMETHYLSILYL]ETHANE

Safety Information

Symbol(GHS)

Signal word

Danger

Hazard statements

H225：Highly Flammable liquid and vapour

H314：Causes severe skin burns and eye damage

Precautionary statements

P210：Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233：Keep container tightly closed.

P240：Ground/bond container and receiving equipment.

P260：Do not breathe dust/fume/gas/mist/vapours/spray.

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310：Immediately call a POISON CENTER or doctor/physician.

P403+P235：Store in a well-ventilated place. Keep cool.

P405：Store locked up.

P501：Dispose of contents/container to..…

Description

1,4-Bis(dimethylamino)-1,1,4,4-tetramethyldisilethylene is used as a reagent for the protection of primary amines with lower pKa values, such as substituted anilines, as their tetramethyldisilylazacyclopentane or Stabase adduct; precursor of tetramethyldisilylthiacyclopentane, a sulfur transfer reagent.
The title reagent is used for the preparation of Stabase derivatives of primary amines, and is particularly useful for the protection of primary aromatic amines with pKa values of 10–11. The protection of substituted anilines is achieved by heating equimolar amounts of the title compound and the anilines in the presence of zinc iodide (0.5 mol %) under a slow stream of nitrogen at 140°C for 5 h. In many cases the products can be purified by vacuum distillation. Cleavage of the Stabase adducts to the corresponding primary amines can be performed in ether in the presence of 2 equiv of methanol and a small amount of p-toluenesulfonic acid monohydrate (0.2 mol %). The tetramethyldisilylazacyclopentane or Stabase adduct (3) is a particularly attractive protecting group due to its ease of preparation, base stability, and facile removal (eq 1).

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Suppliers and manufacturers

• career henan chemical co
  

  $2.00

  1,2-BIS[(DIMETHYLAMINO)DIMETHYLSILYL]ETHANE

  CAS:91166-50-6
• Shanghai Daken Advanced Materials Co.,Ltd
• ATK CHEMICAL COMPANY LIMITED
• Win-Win chemical CO., Limited
• Dayang Chem (Hangzhou) Co.,Ltd.
• Alfa Chemistry
• Coresyn Pharmatech Co., Ltd.
• ShenZhen Trendseen Biological Technology Co.,Ltd.
• Henan Fengda Chemical Co., Ltd
• Aladdin Scientific

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