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ChemicalBook > CAS DataBase List > 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one

  • $17 - $1212.75
  • Product name:5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
  • CAS:89-25-8
  • MF: C10H10N2O
  • MW:174.2
  • EINECS:201-891-0
  • MDL Number:MFCD00003138
  • Synonyms:edaravone-008;MCI-186 - CAS 89-25-8 - Calbiochem;ORGANIC DYE INTERMEDIATES 1-PHENYL 3-METHYL-5 PYRAZOLONE (PMP);3-Methyl-1-phenyl-2-pyrazolin-5-one for synthesis;5-Methyl-2-phenyl-,2-dihydropyrazol-3-one;2-dihydropyrazol-3-one;5-Methyl-2-phenyl-1;1,3,5- pyrazolone (1- phenyl -3- methyl -5- pyrazolone)
Price
  • Brand:Sigma-Aldrich
  • Product number:Y0001138
  • Product namePhenazone impurity A
  • Purity:European Pharmacopoeia (EP) Reference Standard
  • Packaging:y0001138
  • Price:$183
  • Updated:2019/12/2 14:10:03
  • Buy:Buy
  • Brand:Sigma-Aldrich
  • Product number:1040016
  • Product nameAntipyrine Related Compound A
  • Purity:United States Pharmacopeia (USP) Reference Standard
  • Packaging:25mg
  • Price:$1212.75
  • Updated:2019/12/2 14:10:03
  • Buy:Buy
  • Brand:Sigma-Aldrich
  • Product number:M70800
  • Product name3-Methyl-1-phenyl-2-pyrazoline-5-one
  • Purity:99%
  • Packaging:500g
  • Price:$47.1
  • Updated:2019/12/2 14:10:03
  • Buy:Buy
  • Brand:TCI Chemical
  • Product number:M0687
  • Product name3-Methyl-1-phenyl-5-pyrazolone
  • Purity:>98.0%(HPLC)(T)
  • Packaging:25g
  • Price:$17
  • Updated:2019/12/2 14:10:03
  • Buy:Buy
  • Brand:TCI Chemical
  • Product number:M0687
  • Product name3-Methyl-1-phenyl-5-pyrazolone
  • Purity:>98.0%(HPLC)(T)
  • Packaging:500g
  • Price:$36
  • Updated:2019/12/2 14:10:03
  • Buy:Buy
Properties
  • Melting point:126-128 °C(lit.)
  • Boiling point:287 °C265 mm Hg(lit.)
  • Density 1,12 g/cm3
  • refractive index 1.6300 (estimate)
  • Flash point:191°C/17mm
  • storage temp. Store at RT
  • solubility 3.30g/l
  • pka2.73±0.50(Predicted)
  • form Crystalline Powder
  • color Yellow to beige
  • PH4.0-4.4 (H2O, 20℃)(saturated aqueous solution)
  • Water Solubility 3 g/L (20 ºC)
  • Merck 14,6713
  • BRN 609575
  • InChIKeyQELUYTUMUWHWMC-UHFFFAOYSA-N
  • CAS DataBase Reference89-25-8(CAS DataBase Reference)
  • NIST Chemistry Reference3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-(89-25-8)
  • EPA Substance Registry System1-Phenyl-3-methyl-5-pyrazolone (89-25-8)
Safety Information
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements
  • H302:Harmful if swallowed
  • H303:May be harmfulif swallowed
  • H315:Causes skin irritation
  • H319:Causes serious eye irritation
  • H335:May cause respiratory irritation
  • Precautionary statements
  • P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
  • P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

MCI-186 is a free radical scavenger with diverse protective effects in vivo. Most notably, it reduces damage due to ischemia-reperfusion injury in lung, liver, and brain in animal models of transplant, infection, traumatic brain injury, and stroke. MCI-186 provides these protective effects, at least in part, by reducing reactive oxygen species, inhibiting apoptosis, and blocking nonenzymatic peroxidation and lipoxygenase activity.


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