N1,N12-Acetylspermine is a diacetylated derivative of spermine , an endogenous polyamine synthesized from spermidine , that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine. Spermine is required for eukaryotic cell growth and protein synthesis and is involved in the modulation of calcium-dependent immune processes. Upregulation of N1,N12-acetylspermine has been linked to the incidence of cancer, making this natural polyamine a potential biomarker for cancer detection.
![N,N'-[1,4-butanediylbis(imino-3,1-propanediyl)]-acetamide-bis-dihydrochloride (9CI)](https://www.chemicalbook.com/CAS/GIF/77928-71-3.gif)