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N¹,N¹²-Acetylspermine is a diacetylated derivative of spermine , an endogenous polyamine synthesized from spermidine , that displays lower K_m and higher V_max values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine. Spermine is required for eukaryotic cell growth and protein synthesis and is involved in the modulation of calcium-dependent immune processes. Upregulation of N¹,N¹²-acetylspermine has been linked to the incidence of cancer, making this natural polyamine a potential biomarker for cancer detection.

N1,N12-Diacetylspermine Dihydrochloride is a diacetylated derivative of Spermine (S680510) and is recognized as a novel tumor marker in patients with breast and colorectal cancers.

ChEBI: Diacetylspermine is a member of acetamides.

Human Endogenous Metabolite

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