P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
Description
NSC-405020 (7497-07-6) is a membrane type-1 matrix metalloproteinase (MMP14 or MT1-MMP) inhibitor that prevents homodimerization and inhibits MMP14’s protumorigenic activity?in vivo. (IC50?> 100 μM). Inhibition is via interaction with the hemopexin domain (PEX) of MMP14. NSC-405020 does not interfere with the catalytic activity of MT1-MMP or MMP-2.? Suppresses bone erosion in a c-Fos-deficient mouse model.2?Decreases arsenic-mediated invasion of human squamous cell carcinoma HSC5 cells.3
