H361：Suspected of damaging fertility or the unborn child
Precautionary statements
P201：Obtain special instructions before use.
P202：Do not handle until all safety precautions have been read and understood.
P281：Use personal protective equipment as required.
P308+P313：IF exposed or concerned: Get medical advice/attention.
P405：Store locked up.
P501：Dispose of contents/container to..…
Description
Estramustine phosphate is a derivative of estradiol (Item Nos. 20776 | 10006315) that contains a nor-nitrogen mustard group. Estramustine phosphate destabilizes microtubules by binding to microtubule-associated proteins (MAPs) with Kd values of 10 and 15 μM for MAP-1 and MAP-2, respectively. Estramustine induces cell cycle arrest in mitosis at the metaphase stage in DU145 and PC3 prostate cancer cells and induces apoptosis in U87MG human malignant glioma cells. The metabolites of estramustine phosphate have anti-androgenic effects. Formulations containing estramustine phosphate are used in the palliative treatment of prostate cancer.
