Tetrahydrocannabivarin is the propyl analog of Δ9-THC found naturally in Cannabis that acts as a central cannabinoid receptor type 1 (CB1) antagonist (Ki = 75.4 nM) and peripheral cannabinoid (CB2) partial agonist (Ki = 62.8 nM). It also activates transient receptor potential (TRP) channels of the ankyrin type-1 (TRPA1), vanilloid type-1 (TRPV1), and TRPV2 (EC50s = 1.5, 1.5, and 4.1 μM, respectively) and acts as an antagonist of TRPM8 (IC50 = 0.87 μM). This product is intended for forensic and research applications.Cayman Chemical products containing Certified Reference Material (CRM) in the name are highly qualified materials manufactured and tested to meet ISO/IEC 17025:2005 and ISO Guide 34:2009 international guidelines for reference materials. These materials are tested using validated analytical methods on qualified instrumentation to ensure traceability to SI units of measure. Cayman’s CRMs are tested for Homogeneity and Stability and are provided with a certificate stating the CRM property value(s) along with the combined uncertainty of the property value(s). These materials are intended for quantitative applications where quantitative accuracy and uncertainty are critical. Cayman Chemical is committed to providing quality products to its customers as evidenced by its accreditation to the ISO/IEC 17025:2005 and ISO Guide 34:2009 standards. All traceable CRMs may be distinguished by their CofAs and can be downloaded below using the batch number located on the product label. For a representative CofA please contact our technical support.
