3-CYANO-7-ETHOXYCOUMARIN

$39 - $1000

Product name3-CYANO-7-ETHOXYCOUMARIN
Cas No117620-77-6
MFC12H9NO3
MW215.2
EINECS200-562-0
MDL NumberMFCD00467359

Synonyms

7-Ethoxy-2-oxo-2H-chroMene-3-carbonitrile;7-ETHOXYCOUMARIN-3-CARBONITRILE;3-CYANO-7-ETHOXYCOUMARIN;2H-1-Benzopyran-3-carbonitrile,7-ethoxy-2-oxo-(9CI);3-Cyano-7-ethoxycoumarin [7-Ethoxycoumarin-3-carbonitrile] *Cytochrome P450 Substrate*;7-Ethoxy-2-oxo-2H-1-benzopyran-3-carbonitrile;CEC [3-Cyano-7-ethoxycoumarin] *CAS 117620-77-6*;CEC [3-Cyano-7-ethoxycoumarin

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Sigma-Aldrich Cayman Chemical CSNpharm Crysdot Tocris TRC Usbiological Biorbyt Ltd ApexBio Technology AK Scientific Adipogen Life Sciences Apolloscientific SynQuest Laboratories American Custom Chemicals Corporation Biosynth Carbosynth Ambeed DC Chemicals
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20mg 100mg 250mg 500mg 1g 50 5mg 10mg 50mg 25mg 10

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Brand	Packaging	Price	Product name
Adipogen Life Sciences CDX-C0092-M020	20mg	$171	3-Cyano-7-ethoxycoumarin
AK Scientific 2868AA	50mg	$150	7-Ethoxy-2-oxo-2H-chromene-3-carbonitrile
AK Scientific 2868AA	100mg	$215	7-Ethoxy-2-oxo-2H-chromene-3-carbonitrile
Ambeed A743956	250mg	$253	3-Cyano-7-ethoxycoumarin
Ambeed A743956	100mg	$209	3-Cyano-7-ethoxycoumarin
Ambeed A743956	50mg	$118	3-Cyano-7-ethoxycoumarin
Ambeed A743956	10mg	$39	3-Cyano-7-ethoxycoumarin
Ambeed A743956	25mg	$70	3-Cyano-7-ethoxycoumarin
Ambeed A743956	1g	$991	3-Cyano-7-ethoxycoumarin
American Custom Chemicals Corporation CHM0023436	1G	$333.9	3-CYANO-7-ETHOXYCOUMARIN

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Properties

Melting point	210-212°C
Boiling point	396.8±42.0 °C(Predicted)
Density	1.29±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: soluble
form	Solid
color	yellow to orange
λmax	356 nm (Buffer pH7); 355 nm(MeOH)
Biological Applications	As a substrate for measuring cytochrome P450 enzymes activity; cytochrome P450 inhibition assays; drug design; drug metabolism; treating viral or parasite infections.

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H315：Causes skin irritation

H319：Causes serious eye irritation

H335：May cause respiratory irritation

Precautionary statements

P261：Avoid breathing dust/fume/gas/mist/vapours/spray.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

This reagent is a fluorogenic substrate suitable for the continuous determination of cytochrome P450 mixed-function monooxygenases. The product of the reaction is the fluorescent compound 3-cyano-7-hydroxycoumarin (Product No. C 2737). This property has been utilized to determine the activity of CYP1A by measuring the rate of dealkylation of 3-Cyano-7-ethoxycoumarin to this fluorescent product. Fluorescence of 3-cyano-7-hydroxycoumarin occurs at neutral pH with excitation and emission at 408 and 450 nm, respectively. Fluorescent reaction product detection is at least 50-fold more sensitive than that of the product of alkyl resorufin oxidation because of greater rate of turnover of 3-Cyano-7-ethoxycoumarin. The ability to continuously monitor the enzyme reaction at pH 7 is derived from the lower pKa of the 3-cyano-7- hydroxycoumarin product compared to that for 7-ethoxycoumarin. 3-Cyano-7-ethoxycoumarin is a suitable substrate for three of the five principal cytochrome P450 drug metabolizing enzymes, CYP1A1, CYP1A2, CYP2C9, and CYP2C19. It has been used to measure cytochrome P450 mixed-function monooxygenases in rat hepatic microsomal preparations as well as in isolated rat hepatocytes. It was part of a study to examine the expression of CYP2B6 in human liver microsomes, and has been used to characterize Clara and type II cells from rat lung.

Related product price

Sodium cyanoborohydride $9-14550 Coumarin-3-carboxylic acid $5-1068.61 3-CYANO-7-ETHOXYCOUMARIN $39-1000

Suppliers and manufacturers

career henan chemical co

$1.00/1KG

3-CYANO-7-ETHOXYCOUMARIN

CAS:117620-77-6
TargetMol Chemicals Inc.

$30.00/10mg

3-Cyano-7-ethoxycoumarin

CAS:117620-77-6
Dideu Industries Group Limited

$1.10/1g

3-CYANO-7-ETHOXYCOUMARIN

CAS:117620-77-6
ATK CHEMICAL COMPANY LIMITED
Hubei Jusheng Technology Co.,Ltd.
Chongqing Chemdad Co., Ltd
Alchem Pharmtech,Inc.
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Zhejiang J&C Biological Technology Co.,Limited
sgtlifesciences pvt ltd

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