P260：Do not breathe dust/fume/gas/mist/vapours/spray.
P264：Wash hands thoroughly after handling.
P264：Wash skin thouroughly after handling.
P270：Do not eat, drink or smoke when using this product.
P301+P310：IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405：Store locked up.
P501：Dispose of contents/container to..…
Description
MPTP is a neurotoxin used to cause selective destruction of dopaminergic neurons in animal models of parkinsonism. MPTP is metabolized by monoamine oxidase B to produce MPDP+ and MPP+, with MP+ being the active toxic agent. MPP+ induces neurotoxicity primarily by inhibiting complex I of the mitochondrial electron transport chain, resulting in ATP depletion and increased oxidative stress. The key features of different neurotoxic models of Parkinson’s disease, including the MPTP model, have been detailed.
