BD1063 (206996-13-6) is potent and selective sigma-1 antagonist (IC50’s: σ1 = 9nM, σ2 = 449nM).1?BD1063 abolished mechanical and thermal hyperalgesia in mice with carrageenan-induced acute inflammation by enhancing the action of endogenous opioid peptides of immune origin in a σ1 dependent manner.2?BD1063 potentiated μ-opioid antinociception in mice in a sigma-dependent manner.3?BD-1063 has been used in animal models to successfully treat compulsive eating4?and excessive ethanol drinking5.
![1-[2-(3,4-Dichlorophenyl)ethyl]-4-Methylpiperazine Dihydrochloride](https://www.chemicalbook.com/CAS/GIF/206996-13-6.gif)
