JWH 018 (1-
pentyl-
3-
(1-
naphthoyl)indole) is a synthetic cannabinoid (CB) that potently activates the central CB
1 and peripheral CB
2 receptors (K
i = 9.0 and 2.94 nM, respectively).
1 This cannabimimetic compound has frequently been found in herbal blends.
2,3,4 JWH 018 2’-
naphthyl-
N-
(2,2-
dimethylpropyl) isomer differs structurally from JWH 018 by having the naphthyl group attached at the 2’ position and 2,2-
dimethylpropyl in place of the pentyl chain. The biological activities of this compound have not been characterized.
