[1-(2,2-dimethylpropyl)indol-3-yl]-naphthalen-1-ylmethanone

JWH 018 is a synthetic cannabinoid (CB) that potently activates the CB₁ and CB₂ receptors (K_i = 9.0 and 2.94 nM, respectively).¹ This cannabimimetic compound has frequently been found in herbal blends. ^2,3,4 JWH 018 N-(2,2-dimethylpropyl) isomer differs from JWH 018 structurally by having a 2,2-dimethylpropyl group, rather than a pentyl chain, extending from the indole group. The biological activities of this compound have not been characterized.