C24:1 3’-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids. It is the predominate sulfatide species in mature myelin, and it accumulates at a higher rate than C24 3’-sulfo galactosylceramide in rat cerebellum from seven to 32 days of age when active myelination occurs.
1 It interacts with C-type lectins and immunoglobulin-like receptors with the highest affinity for LMIR5.
2 It induces production of MCP-1 in basophils but not mast cells and increases the activation of NFAT in a reporter assay
via LMIR5. C24:1 3’-sulfo Galactosylceramide is an immunodominant species in myelin, is bound by CD1d
in vitro, and increases proliferation in isolated mouse splenocytes.
3 It reduces symptoms and increases survival in a mouse model of chronic relapsing-remitting experimental autoimmune encephalomyelitis (EAE) when used at a dose of 20 μg.
4 It also decreases the number of inflammatory lesions and infiltrating mononuclear cells in the lumbar spinal cord of EAE mice.
As this product is derived from a natural source, there may be variations in the sphingoid backbone.
