(R)-4-Hydroxy-5-(hydroxymethyl)-3-(1-oxohexadecyl)-2(5H)-furanone

(±)-RK-682 (150627-37-5) is a protein tyrosine phosphatase inhibitor (IC50‘s = 54 7 μM for CD45, 2.0 μM for VHR; did not inhibit cdc25B) originally isolated from the fermentation of Streptomyces sp. 88-682.1?Inhibits cell cycle at G1/S. RK-682 has also been shown to inhibit PLA2 (IC50?= 16 μM)2, HIV-1 protease (IC50?= 84 μlM)3, and heparanase (IC50?= 17 μM)4. Natural RK-682 (R-isomer) and synthetic racemic material have identical phosphatase activity.5?Care should be taken when using RK-682 in the presence of metal salts – because it readily forms metal complexes that affects its phosphatase inhibitory activity.6?RK-682 has been identified as a potential promiscuous inhibitor.7