Agonists of the peripheral cannabinoid (CB) receptor CB2 may have antinociceptive and anti-inflammatory effects, as well as prevent osteoporosis. 4-Quinolone-3-carboxamide Furan CB2 Agonist is a high affinity ligand of CB2 (Ki = 8.5 nM) with little affinity for CB1 (Ki >10000 nM). This compound demonstrates antinociceptive efficacy in the mouse formalin test at 1 mg/kg, an action which is blocked by a CB2-selective antagonist, AM630.
