Numerous analogs of fatty acyl ethanolamides potentiate the intrinsic biological activity of endocannabinoids.
1 This potentiation is ascribed either to inhibition of AEA reuptake into neurons, or inhibition of fatty acid amide hydrolase (FAAH) within the neurons.
2 However, Ueda,
et al. has recently cloned another amidase, the acidic PEAase that promotes the hydrolysis of palmitoylethanolamide.
3 N-
Cyclohexanecarbonyltetradecylamine is an analog of N-
cyclohexanecarbonyl-
pentadecylamine, a selective inhibitor of acidic PEAase with an IC
50 value of 4.5 μM, that contains 1 less carbon in the alkyl chain.
4 The biological activity of N-
cyclohexanecarbonyltetradecylamine has not been documented.
