C22 Glucosylceramide is an endogenous glucosylceramide.
1,2,3 Glucosylceramides are major constituents of skin lipid membranes where they play a role in maintaining the water permeability barrier. They are precursors in the synthesis of lactosylceramide , as well as oligoglycolipids and gangliosides. Phospholipase A
2 (PLA
2) type XIIA knockdown increases C22 glucosylceramide expression in rat brain.
3 It is also increased in the brain, but not the liver or spinal cord, of mice fed a methionine-restricted diet.
2 In human athletes, plasma levels of C22 glucosylceramide increase during exercise and return to basal levels during recovery.
1 This product contains C22 glucosylceramide isolated from bovine buttermilk.
As this product is derived from a natural source, there may be variations in the sphingoid backbone.
