Description
C22 Glucosylceramide is an endogenous glucosylceramide.
1,2,3 Glucosylceramides are major constituents of skin lipid membranes where they play a role in maintaining the water permeability barrier. They are precursors in the synthesis of lactosylceramide , as well as oligoglycolipids and gangliosides. Phospholipase A
2 (PLA
2) type XIIA knockdown increases C22 glucosylceramide expression in rat brain.
3 It is also increased in the brain, but not the liver or spinal cord, of mice fed a methionine-restricted diet.
2 In human athletes, plasma levels of C22 glucosylceramide increase during exercise and return to basal levels during recovery.
1 This product contains C22 glucosylceramide isolated from bovine buttermilk.
As this product is derived from a natural source, there may be variations in the sphingoid backbone.
References
1. Bergman, B.C., Brozinick, J.T., Strauss, A., et al. Serum sphingolipids: Relationships to insulin sensitivity and changes with exercise in humans Am. J. Physiol. Endocrinol. Metab. 309(4),E398-E408(2015).
2. Jové, M., Ayala, V., Ramírez-Nú?ez, O., et al. Specific lipidome signatures in central nervous system from methionine-restricted mice J. Proteome Res. 12(6),2679-2689(2013).
3. Ee, S.-M., Lo, Y.-L., Shui, G., et al. Distribution of secretory phospholipase A2 XIIA in the brain and its role in lipid metabolism and cognition Mol. Neurobiol. 50(1),60-75(2014).
