CP 47,497 is a bicyclic cannabinoid analog with potent analgesic activity. It is comparable or more potent than Δ9-tetrahydrocannabinol in analgesic, motor depressant, anticonvulsant and hypothermic effects in mice, rats, and dogs. The levorotatory enantiomer, (?)-CP 47,497 avidly binds the CB1 receptor (Ki = 2.1 nM).